Efficient copper-catalyzed amination of aryl halides with amines and N H heterocycles using rac-BINOL as ligand
نویسندگان
چکیده
A highly efficient copper-catalyzed system using commercially available racemic 1,1′-binaphthyl-2,2′-diol (rac-BINOL) as the ligand was eveloped for amination of aryl halides and heteroaryl halides with alkyl amines and N H heterocycles. Good to high yields were obtained for aryl romides and heteroaryl chlorides. The commercially available rac-BINOL ligand with excellent stability and high efficiency for aryl bromides nd heteroaryl chlorides ultimately make this protocol of potentially practical utility. 2006 Elsevier B.V. All rights reserved.
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